Welcome to the Prevention of Respiratory Insufficiency after Surgical Management (PRISM) Trial.

PRISM is an international, multi-centre, pragmatic, randomised controlled trial with open study group allocation, to determine if routine continuous positive airway pressure (CPAP) for four hours immediately after major abdominal surgery is effective prophylaxis against postoperative pneumonia, re-intubation or death.

The PRISM management team is based at Queen Mary University of London in the UK. We opened in early 2016, and have recruited 4800 patients across more than 60 sites in Italy, Norway, South Africa, Spain, Sweden and the UK. We are very grateful to all of our local investigators for their help and support.

We are delighted to announce that the main PRISM manuscript will soon be published in the Lancet Respiratory Medicine (in press):
DOI: 10.1016/S2213-2600(21)00089-8
The paper will be published on an open access basis, but you are free to download and read the final authors version here.

PRISM Final Authors Manuscript

In addition we have prepared a short video to explain the findings:

Please contact us if you have any queries, and follow us on twitter @prismtrial for regular news.

Best wishes,

The PRISM study team

Last updated - 2021-05-18