Welcome to the Prevention of Respiratory Insufficiency after Surgical Management (PRISM) Trial.

PRISM is an international, multi-centre, pragmatic, randomised controlled trial with open study group allocation, to determine if routine continuous positive airway pressure (CPAP) for four hours immediately after major abdominal surgery is effective prophylaxis against postoperative pneumonia, re-intubation or death.

The PRISM management team is based at Queen Mary University of London in the UK. We opened in early 2016, and now has more than 50 sites in Italy, Norway, South Africa, Spain, Sweden and the UK. We recently recruited our 2000th patient and we are now on course to finish the trial on time by the end of 2019. We are very grateful to all of our local investigators for their help and support.

Please feel free to browse our website which is the central communication hub for the trial. We will update the site regularly as the trial progresses. Please contact us if you have any queries, and follow us on twitter @prismtrial for regular news.


Best wishes,

The PRISM trial team

Last updated - 2017-11-21